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临床资料患者男性45岁
系"活动后胸闷气喘2年
加重1周"入院
2013年开始出现活动耐量降低
劳力性胸闷、气喘
进行性加重
渐夜间不能平卧
多次在我院住院治疗
明确诊断为"扩张型心肌病、心功Ⅲ级"
长期服用"贝那普利、倍他乐克、地高辛、呋塞米、螺内酯和胺碘酮"等药物
但症状仍有反复
药物治疗效果不佳
2015年5月因心衰症状加重考虑行心脏
William T. Abraham,JoAnn Lindenfeld,Vivek Y. Reddy,Gerd Hasenfuss,Karl-Heinz Kuck,John Boscardin,Robert Gibbons,Daniel Burkhoff.A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation in Patients With Moderately Reduced Left Ventricular Ejection Fraction and a Narrow QRS Duration: Study Rationale and Design[J].Journal of Cardiac Failure,2015.
James Winter,Kieran E. Brack,John H. Coote,G. André Ng.Cardiac contractility modulation increases action potential duration dispersion and decreases ventricular fibrillation threshold via β1-adrenoceptor activation in the crystalloid perfused normal rabbit heart[J].International Journal of Cardiology,2014.
Francesco Giallauria,Carlo Vigorito,Massimo F. Piepoli,Andrew J. Stewart Coats.Effects of cardiac contractility modulation by non-excitatory electrical stimulation on exercise capacity and quality of life: An individual patient's data meta-analysis of randomized controlled trials[J].International Journal of Cardiology,2014.
Qing Zhang,Yat-Sun Chan,Yu-Jia Liang,Fang Fang,Yat-Yin Lam,Chin-Pang Chan,Alex Pui-Wei Lee,Karl Chi-Yuen Chan,Eugene B. Wu,Cheuk-Man Yu.Comparison of left ventricular reverse remodeling induced by cardiac contractility modulation and cardiac resynchronization therapy in heart failure patients with different QRS durations[J].International Journal of Cardiology,2012.
James Winter,Kieran E. Brack,G. André Ng.The acute inotropic effects of cardiac contractility modulation (CCM) are associated with action potential duration shortening and mediated by β1-adrenoceptor signalling[J].Journal of Molecular and Cellular Cardiology,2011(2).
Alan Kadish,Koonlawee Nademanee,Kent Volosin,Steven Krueger,Suresh Neelagaru,Nirav Raval,Owen Obel,Stanislav Weiner,Marc Wish,Peter Carson,Kenneth Ellenbogen,Robert Bourge,Michael Parides,Richard P. Chiacchierini,Rochelle Goldsmith,Sidney Goldstein,Yuval Mika,Daniel Burkhoff,William T. Abraham.A randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure[J].American Heart Journal,2011(2).
Makoto Imai,Sharad Rastogi,Ramesh C. Gupta,Sudhish Mishra,Victor G. Sharov,William C. Stanley,Yuval Mika,Benny Rousso,Daniel Burkhoff,Shlomo Ben-Haim,Hani N. Sabbah.Therapy With Cardiac Contractility Modulation Electrical Signals Improves Left Ventricular Function and Remodeling in Dogs With Chronic Heart Failure[J].Journal of the American College of Cardiology,2007(21).
Suresh B. Neelagaru,Javier E. Sanchez,Stanley K. Lau,Steven M. Greenberg,Nirav Y. Raval,Seth Worley,Jill Kalman,Andrew D. Merliss,Steven Krueger,Mark Wood,Marc Wish,Daniel Burkhoff,Koonlawee Nademanee.Nonexcitatory, cardiac contractility modulation electrical impulses: Feasibility study for advanced heart failure in patients with normal QRS duration[J].Heart Rhythm,2006(10).
Cheuk-Man Yu,Gabe B. Bleeker,Jeffrey Wing-Hong Fung,Martin J. Schalij,Qing Zhang,Ernst E. van der Wall,Yat-Sun Chan,Shun-Ling Kong,Jeroen J. Bax.Left Ventricular Reverse Remodeling but Not Clinical Improvement Predicts Long-Term Survival After Cardiac Resynchronization Therapy[J].Circulation,2005(11).
Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality The Framingham Heart Study[J].Circulation,2003(23).
HARVEY D. WHITE,ROBIN M. NORRIS,MICHAEL A. BROWN,PETER W. T. BRANDT,RALPH M. L. WHITLOCK,CHRISTOPHER J. WILD.Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction[J].Circulation,1987(1).
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