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正>近年来
I
f
通道的发现与深入研究是基础心脏电生理领域最瞩目的进展
这项重大发现是以1999年发现I
f
通道的亚单位HCN通道为标志
随后十几年中
该学术领域出现了颠覆性进展。一.心脏电活动起源的经典认识每位心电学入门者都熟悉心脏电活动起源的几个基本概念。
<正>近年来
I_f通道的发现与深入研究是基础心脏电生理领域最瞩目的进展
这项重大发现是以1999年发现I_f通道的亚单位HCN通道为标志
随后十几年中
该学术领域出现了颠覆性进展。一.心脏电活动起源的经典认识每位心电学入门者都熟悉心脏电活动起源的几个基本概念。
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Mechanisms of Ventricular Arrhythmias: From Molecular Fluctuations to Electrical Turbulence [J] . Zhilin Qu,James N. Weiss. Annual Review of Physiology . 2015
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Effect of I f -Channel Inhibition on Hemodynamic Status and Exercise Tolerance in Heart Failure With Preserved Ejection Fraction [J] . Wojciech Kosmala,David J. Holland,Aleksandra Rojek,Leah Wright,Monika Przewlocka-Kosmala,Thomas H. Marwick. Journal of the American College of Cardiology . 2013 (15)
Upregulation of the Hyperpolarization-Activated Current Increases Pacemaker Activity of the Sinoatrial Node and Heart Rate During Pregnancy in Mice [J] . Nabil El Khoury,Sophie Mathieu,Laurine Marger,Jenna Ross,Gracia El Gebeily,Nathalie Ethier,Céline Fiset. Circulation . 2013 (20)
Reverse Remodeling and the Risk of Ventricular Tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy) [J] . Alon Barsheshet,Paul J. Wang,Arthur J. Moss,Scott D. Solomon,Amin Al-Ahmad,Scott McNitt,Elyse Foster,David T. Huang,Helmut U. Klein,Wojciech Zareba,Michael Eldar,Ilan Goldenberg. Journal of the American College of Cardiology . 2011 (24)
Funny Current Downregulation and Sinus Node Dysfunction Associated With Atrial Tachyarrhythmia: A Molecular Basis for Tachycardia-Bradycardia Syndrome [J] . Yung-Hsin Yeh,Brett Burstein,Xiao Yan Qi,Masao Sakabe,Denis Chartier,Philippe Comtois,Zhiguo Wang,Chi-Tai Kuo,Stanley Nattel. Circulation . 2009 (12)
Direct Inhibition of Cardiac Hyperpolarization-Activated Cyclic Nucleotide–Gated Pacemaker Channels by Clonidine [J] . Anne Knaus,Xiangang Zong,Nadine Beetz,Roland Jahns,Martin J. Lohse,Martin Biel,Lutz Hein. Circulation . 2007 (7)
Single-Channel Properties Support a Potential Contribution of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels and If to Cardiac Arrhythmias [J] . Guido Michels,Fikret Er,Ismail Khan,Michael Südkamp,Stefan Herzig,Uta C. Hoppe. Circulation . 2005 (4)
HYPERPOLARIZATION-ACTIVATED CATION CURRENTS: From Molecules to Physiological Function [J] . Richard B. Robinson,Steven A. Siegelbaum. Annual Review of Physiology . 2003
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