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目的探讨冠脉造影患者冠状动脉狭窄程度和高密度脂蛋白(High-density lipoprotein
HDL)亚类的关系。方法 1抽取2013年至2015年因疑诊冠心病(Coronary Heart Disease
CHD)入住我院老年医学科、心内科行冠状动脉造影(Coronary arteriography
CAG)的患者361例
通过CAG确诊为CHD患者(至少有一支冠状动脉或分支狭窄>50%)237例
其中男138例
女99例
平均年龄(60.31±8.59)
未诊断CHD患者124例
男50例
女74例
平均年龄(59.22±13.23);2抽取患者空腹12 h静脉血
选择双向电泳加免疫印迹检测法24h内测定HDL亚类
对患者冠脉造影结果(采用Gensini评分)评价冠状动脉狭窄程度;3计量资料用χ軘±s表示
定性资料用χ2检验
两组比较采用独立样本的t检验
logisitic回归分析与冠心病相关因素
有序Ordinal回归分析与冠状动脉狭窄程度的关系。结果 1 CHD组中中、重度患者组Preβ1-HDL、HDL3b较非CHD组明显增高(p<0.05)
CHD组中轻、中、重度患者组HDL3c较非CHD组明显增高(p<0.05)
而HDL2b较非CHD组显著减少(p<0.05)
随着冠状动脉狭窄程度的增加
Preβ1-HDL、HDL3b、HDL3c出现增高趋势
而HDL2b则降低;2二元Logistic回归分析
HDL亚类中Preβ1-HDL
HDL3b
HDL3c与CHD呈正相关(p<0.05)
HDL2b与CHD呈负相关;有序Ordinal回归
Preβ1-HDL与冠状动脉狭窄程度呈正相关
HDL2b与冠状动脉狭窄程度呈负相关。结论 Preβ1-HDL、HDL3b高对冠心病有风险
HDL2b是冠心病保护因素
在临床诊断治疗中
HDL2b值有可能做为冠心病预测因素
Preβ1-HDL、HDL2b可为预测和诊断CHD提供重要参考依据
冠心病的防治不仅要改善和促进胆固醇逆转运还要调节血脂及调整HDL亚类的构成比。
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