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衰老是多种心血管疾病发生发展的独立危险因素。随着老年化的进展
心律失常如病窦综合征、心房颤动、室性心律失常等的发病率和病死率显著增加。目前对老年性心律失常增龄性改变的分子机制认识尚不清楚
治疗亦仅限于对症治疗策略。因此
现就衰老相关心律失常发生的结构和功能性改变、流行病学、诊治特殊性展开综述。一.衰老所致心脏结构和功能的增龄性改变机体随年龄增加出现窦房结起搏细胞进行性减少
心肌细胞及间质纤维化明显增加
钠、钾、钙离子
Sandra A. Jones,Matthew K. Lancaster.Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium[J].Mechanisms of Ageing and Development,2015.
XIAOXIAO GUO,SU YUAN,ZHENYU LIU,QUAN FANG.Oxidation‐ and CaMKII‐Mediated Sarcoplasmic Reticulum Ca2+ Leak Triggers Atrial Fibrillation in Aging[J].J Cardiovasc Electrophysiol,2014(6).
Guo‐Jun Xu,Tian‐Yi Gan,Bao‐Peng Tang,Zu‐Heng Chen,Tao Jiang,Jian‐Guo Song,Xia Guo,Jin‐xin Li.Age‐related changes in cellular electrophysiology and calcium handling for atrial fibrillation[J].J. Cell. Mol. Med.,2013(9).
Tao Luo,Cui-Xian Chang,Xin Zhou,Shi-Kui Gu,Tie-Ming Jiang,Yu-Ming Li.Characterization of atrial histopathological and electrophysiologicalchanges in a mouse model of aging[J].International Journal of Molecular Medicine,2013(1).
Alan S. Go,Dariush Mozaffarian,Véronique L. Roger,Emelia J. Benjamin,Jarett D. Berry,William B. Borden,Dawn M. Bravata,Shifan Dai,Earl S. Ford,Caroline S. Fox,Sheila Franco,Heather J. Fullerton,Cathleen Gillespie,Susan M. Hailpern,John A. Heit,Virginia J. Howard,Mark D. Huffman,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,David Magid,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Darren K. McGuire,Emile R. Mohler,Claudia S. Moy,Mi.Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association[J].Circulation,2013(1).
John A. Jansen,Toon A.B. van Veen,Sanne de Jong,Roel van der Nagel,Leonie van Stuijvenberg,Helen Driessen,Ronald Labzowski,Carolin M. Oefner,Astrid A. Bosch,Tri Q. Nguyen,Roel Goldschmeding,Marc A. Vos,Jacques M.T. de Bakker,Harold V.M. van Rijen.Reduced Cx43 Expression Triggers Increased Fibrosis Due to Enhanced Fibroblast Activity[J].Circulation: Arrhythmia and Electrophysiology,2012(2).
Samy Makary,Niels Voigt,Ange Maguy,Reza Wakili,Kunihiro Nishida,Masahide Harada,Dobromir Dobrev,Stanley Nattel.Differential Protein Kinase C Isoform Regulation and Increased Constitutive Activity of Acetylcholine-Regulated Potassium Channels in Atrial Remodeling[J].Circulation Research,2011(9).
Xiaojin Hao,Yanmin Zhang,Xinzhao Zhang,Mahesh Nirmalan,Laura Davies,Dimitrios Konstantinou,Fei Yin,Halina Dobrzynski,Xin Wang,Andrew Grace,Henggui Zhang,Mark Boyett,Christopher L.-H. Huang,Ming Lei.TGF-β1-Mediated Fibrosis and Ion Channel Remodeling Are Key Mechanisms in Producing the Sinus Node Dysfunction Associated With SCN5A Deficiency and Aging[J].Circulation: Arrhythmia and Electrophysiology,2011(3).
Andrew E. Epstein,John P. DiMarco,Kenneth A. Ellenbogen,N A. Mark Estes,Roger A. Freedman,Leonard S. Gettes,A Marc Gillinov,Gabriel Gregoratos,Stephen C. Hammill,David L. Hayes,Mark A. Hlatky,L Kristin Newby,Richard L. Page,Mark H. Schoenfeld,Michael J. Silka,Lynne Warner Stevenson,Michael O. Sweeney,Sidney C. Smith,Alice K. Jacobs,Cynthia D. Adams,Jeffrey L. Anderson,Christopher E. Buller,Mark A. Creager,Steven M. Ettinger,David P. Faxon,Jonathan L. Halperin,Loren F. Hiratzka,Sharon A. Hunt,Harlan M. Krumholz,Frederick G. Kushner,Bruce W. Lytle,Rick A. Nishimura,Joseph P. Ornato,Richard L. Page,Barbara Riegel,Lynn G. Tarkington,Clyde W. Yancy.ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices)[J].Circulation,2008(21).
Yoko Miyasaka,Marion E. Barnes,Bernard J. Gersh,Stephen S. Cha,Kent R. Bailey,Walter P. Abhayaratna,James B. Seward,Teresa S.M. Tsang.Secular Trends in Incidence of Atrial Fibrillation in Olmsted County, Minnesota, 1980 to 2000, and Implications on the Projections for Future Prevalence[J].Circulation,2006(2).
Rania Gaspo,Ralph F. Bosch,Elias Bou-Abboud,Stanley Nattel.Tachycardia-Induced Changes in Na sup + Current in a Chronic Dog Model of Atrial Fibrillation[J].Circulation Research,1997.
曹克将.抗心律失常药物在老年患者中的应用[J].中华老年心脑血管病杂志,2007(11).
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