Association between serum level of sST2, high-sensitivity C-reactive protein and atrial structure remodeling in patients with atrial fibrillation

Yang shuhan; Chen hongwei; Liu yanbin; Xing yongsheng

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Association between serum level of sST2, high-sensitivity C-reactive protein and atrial structure remodeling in patients with atrial fibrillation

更新时间：2025-10-15

- Association between serum level of sST2, high-sensitivity C-reactive protein and atrial structure remodeling in patients with atrial fibrillation
- Vol. 29, Issue 2, Pages: 123-126(2020)
- 作者机构：
  
  河南新乡市中心医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.75
- Published：2020
- 稿件说明：
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[1]杨树涵,陈红伟,刘艳宾,邢永生.房颤患者sST2及hs-CRP与左房重构的关系[J].临床心电学杂志,2020,29(02):123-126.

Yang shuhan, Chen hongwei, Liu yanbin, et al. Association between serum level of sST2, high-sensitivity C-reactive protein and atrial structure remodeling in patients with atrial fibrillation[J]. 2020, 29(2): 123-126.
[1]杨树涵,陈红伟,刘艳宾,邢永生.房颤患者sST2及hs-CRP与左房重构的关系[J].临床心电学杂志,2020,29(02):123-126. DOI：

Yang shuhan, Chen hongwei, Liu yanbin, et al. Association between serum level of sST2, high-sensitivity C-reactive protein and atrial structure remodeling in patients with atrial fibrillation[J]. 2020, 29(2): 123-126. DOI：

摘要

目的评价心房颤动（AF）患者sST2、高敏C反应蛋白（hs-CRP）水平与心脏结构的关系。方法选择在我院确诊AF患者64例

持续性AF组31例

阵发性AF组33例

同期健康体检者30例为对照组。行心脏超声学检查

并采用酶联免疫吸附法检测sST2、hs-CRP水平

分析sST2、hs-CRP和心脏超声学指标的关系。结果 3组患者在左房内径（LAD）、hs-CRP和sST2水平上有明显差异（p<0.05）。Spearman相关分析显示AF患者年龄、LAD、hs-CRP与sST2水平呈正相关（r=0.188、0.454、0.357

p<0.05）。多元线性回归分析显示LAD和hs-CRP是影响AF患者sST2水平的因素。Logistic回归分析显示

LAD、hs-CRP和sST2水平是影响AF发生的危险因素。结论 sST2和炎症参与AF患者左房重构

和AF发生相关。

Abstract

Objective To evaluate association between serum level of sST2

high-sensitivity C-reactive protein(hs-CRP) and cardiac structure in patients with atrial fibrillation(Af). Methods 64 patients with Af were divided into persistent Af group(n=31) and paroxysmal Af group(n=33)

and 30 patients without Af were included as control group. Detailed informations were recorded including the basic characteristics

the levels of plasma sST2

hs-CRP and transthoracic echocardiography indices. Results There were significant differences in plasma level of sST2

hs-CRP and Left atrial diameter(LAD) between 3 groups. Spearman correlation analysis showed that age

LAD and hs-CRP were positively correlated with sST2 level in Af patients(r=0.188

0.454

0.357

p<0.05). Multivariate linear regression analysis showed that LAD and hs-CRP were the factors affecting the level of sST2 in Af patients. Logistic regression analysis presented that LAD

hs-CRP and sST2 levels were risk factors for Af. Conclusions sST2 and inflammation are involved in left atrial remodeling in Af patients

and are associated with the occurrence of Af.

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references

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