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中国人民解放军总医院心血管病医学部
Published:2022
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Shixiangmin, Li jian, Li shixing, et al. The role of transient outward potassium current in the arrhythmogenesis of polymorphic ventricular tachycardia in patients with coronary artery disease and the prophylactic mechanism of quinidine[J]. 2022, (1): 65-68.
短联律间期室早引发的多形性室性心动过速(PVT)是冠心病(CAD)患者常见的危及生命的心律失常之一,血运重建和传统的抗心律失常药物无法有效预防这种恶性心律失常。最近的研究表明,2相折返可能是心肌缺血相关PVT的潜在机制,这与Brugada综合征和特发性心室颤动的发生机制相类似。瞬时外向钾电流(Ito)在2相折返的形成中起重要作用,奎尼丁已被证实可抑制Ito并预防CAD患者PVT的发生。
Polymorphic ventricular tachycardia(PVT) triggered by short-coupled premature ventricular complex is a common life-threatening arrhythmia in coronary artery disease(CAD)
revascularization and traditional anti-arrhythmic drugs could not effectively prevent this malignant arrhythmia. Recent study suggested that phase 2reentry could be the underlying mechanism of myocardial ischemia-related PVT
which was similar to that of Brugada syndrome and idiopathic ventricular fibrillation. Transient outward potassium current(Ito) plays an important role in the development of phase 2 reentry
and quinidine has been proved to inhibit Ito and prevent the occurrence of PVT in patients with CAD.
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