Objective To analyze the efficacy of dual antiplatelet therapy for patients with coronary heart disease complicated with atrial fibrillation

and to evaluate the risk of embolism and bleeding

as well as the effect on vascular endothelial function. Methods One hundred and seven patients with coronary heart disease complicated with atrial fibrillation were randomly divided into two groups. Fifty-three patients in the control group were given warfarin sodium for anticoagulant therapy

and 54 patients in the observation group were given clopidogrel hydrogen sulfate combined with aspirin for dual antiplatelet therapy. The risk of embolism and bleeding

incidence of adverse events and vascular endothelial function were compared between the two groups.Results After intervention

the observation group had lower HAS--BLED and CHADS2 scores

primary end point events

bleeding

serum ET-1 level and incidence of secondary end point events

and the serum VECF level and serum NO level were higher than those in the control group（p <0.05）. Conclusions Clopidogrel bisulfate combined with aspirin can effectively improve vascular endothelial function

reduce the risk of bleeding and thrombosis

and reduce the incidence of adverse events in patients with coronary heart disease combined with atrial fibrillation.