Objective To study the influencing factors of antipsychotic drugs on cardiovascular disease risk in patients with first-episode schizophrenia. Methods A total of 60 first-episode schizophrenia patients admitted to our hospital from January 2021 to May 2021 were selected as the research group

and 30 healthy volunteers who underwent physical health examinations during the same period were selected as the control group. Routine ECG examinations were performed on the day after the control group was enrolled and the study group before treatment and at the end of the second

fourth

eighth

and twelfth week after treatment

to compare the incidence of abnormal ECG such as QTc interval prolongation and T wave changes between the two groups. The study group was followed up for 1year

the incidence of cardiac adverse events was counted

and the groups were divided according to the occurrence of cardiac adverse events（no adverse cardiac events group and adverse cardiac events group）

and the effects of antipsychotic drugs on the heart of patients with first-onset schizophrenia were analyzed. The impact of antipsychotic drugs on vascular disease risk were analyzed. Results After inspection

the QTc interval of the study group was prolonged and the incidence of T wave changes was higher than that of the control group（p<0.05）. The incidence of adverse cardiac events in the study group was 36.67%（22/60）. After multi-factor analysis

smoking history

type of antipsychotics

metabolic syndrome

QTc interval prolongation

and T wave changes are independent risk factors for vascular disease（p<0.05）. Conclusions After the first episode of schizophrenia is treated with antipsychotic drugs

there is a higher probability of cardiovascular disease. Smoking history

type of antipsychotics

metabolic syndrome

QTc interval prolongation

and T wave changes are independent risk factors of cardiovascular disease in first-episode schizophrenia patients.