ZHANG Bin.ST-Segment Elevation in the Precordial Leads: A Vector Masquerade — Analysis and Clinical Implications of Electrocardiographic Misinterpretation[J].J Clin Electrocardiol,2026,35(01):12-18.
ZHANG Bin.ST-Segment Elevation in the Precordial Leads: A Vector Masquerade — Analysis and Clinical Implications of Electrocardiographic Misinterpretation[J].J Clin Electrocardiol,2026,35(01):12-18.DOI:
ST-Segment Elevation in the Precordial Leads: A Vector Masquerade — Analysis and Clinical Implications of Electrocardiographic Misinterpretation
A 65-year-old male patient with a history of well-controlled hypertension presented with acute oppressive precordial pain lasting 4 hours. The initial electrocardiogram (ECG) showed ST-segment elevation in the inferior (Ⅱ
Ⅲ
aVF) and anterior (V
1
~V
6
) leads
with more pronounced elevation in the precordial leads V
1
~V
3
. The initial septal vector remained normal. Emergency coronary angiography confirmed a proximal occlusion of the right coronary artery (RCA)
with non-culprit lesions present in the left anterior descending (LAD) and left circumflex (LCX) arteries. Percutaneous coronary intervention successfully revascularized the RCA
leading to symptom resolution. Post-procedural ECG demonstrated rapid resolution of ST-segment elevation in the anterior leads with preserved R-wave progression. A follow-up ECG one week later revealed pathological Q waves and T-wave inversion in the inferior leads
while the anterior leads returned to normal. This case challenges the traditional paradigm that "ST-segment elevation in V
1
-V
3
indicates anterior (septal
) myocardial infarction due to LAD occlusion
" highlighting the critical importance of accurately understanding the cardiac anatomical regions corresponding to precordial leads (particularly the right ventricle) and interpreting ECG vector changes for precise infarct localization in acute myocardial infarction. Correlation with cardiac magnetic resonance (CMR) imaging can aid in clarifying the relationship between lead positioning and the area of myocardial injury. Clinicians must remain vigilant regarding such ECG patterns to avoid misidentification of the culprit vessel.
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references
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