Multivariate Correlation Analysis of Risk Factors for Coronary Heart Disease Complicated with Chronic Heart Failure

Li Jiaxin; Fan Ping

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Multivariate Correlation Analysis of Risk Factors for Coronary Heart Disease Complicated with Chronic Heart Failure

Treatise | 更新时间：2026-04-28

- Multivariate Correlation Analysis of Risk Factors for Coronary Heart Disease Complicated with Chronic Heart Failure
- J Clin Electrocardiol Vol. 35, Issue 2, Pages: 129-136(2026)
- 作者机构：
  
  1.830002 新疆乌鲁木齐，新疆医科大学第一附属医院心内科（李佳欣）
  2.830002 新疆乌鲁木齐，新疆医科大学第一附属医院心功能科（范平）
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.7　R540.4+1
- Received：25 December 2025，
  
  Revised：2026-01-28，
  
  Accepted：02 February 2026，
  
  Published：28 April 2026
- 稿件说明：
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李佳欣, 范平. 冠心病合并慢性心力衰竭发生风险的多因素相关分析[J]. 临床心电学杂志, 2026, 35(2): 129-136.

Li Jiaxin,Fan Ping.Multivariate Correlation Analysis of Risk Factors for Coronary Heart Disease Complicated with Chronic Heart Failure[J].J Clin Electrocardiol,2026,35(02):129-136.
李佳欣, 范平. 冠心病合并慢性心力衰竭发生风险的多因素相关分析[J]. 临床心电学杂志, 2026, 35(2): 129-136. DOI：

Li Jiaxin,Fan Ping.Multivariate Correlation Analysis of Risk Factors for Coronary Heart Disease Complicated with Chronic Heart Failure[J].J Clin Electrocardiol,2026,35(02):129-136. DOI：

摘要

目的

探讨临床资料和24小时动态心电图与冠心病（CHD）患者合并慢性心力衰竭（CHF）的相关性。

方法

本研究为一项回顾性横断面研究，选取2023年1月至2024年12月期间于新疆医科大学第一附属医院或4家合作中心医院住院接受诊治的424例CHD患者作为研究对象，收集患者住院期间临床资料，包括年龄、性别、白细胞、红细胞、血小板、白蛋白、天门冬氨酸氨基转移酶（AST）、估算肾小管滤过率（eGFR）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、糖化血红蛋白、左心室收缩末期内径（LVESD）、肺动脉收缩压（PASP）和左心室射血分数（LVEF）等指标以及24小时动态心电图中的最慢心率、最快心率、全程每5分钟NN间期均值标准差（SDNN）、三角指数、QT平均QTc间期和心率减速力（DC）等监测指标。根据是否合并CHF将CHD患者分为心衰组（

=227）和非心衰组（

=197），对比两组患者的临床特征，采用多因素logistic回归分析CHD患者合并CHF的相关因素。

结果

多因素logistic回归分析结果显示，在动态心电图监测指标中，SDANN（

=0.943，95%

：0.906~0.981，

0.05）与CHD合并CHF呈负相关；QT平均QTc间期（

=1.008，95%

：1.001~1.014，

0.05）与CHD合并CHF呈正相关。在临床资料中，白蛋白（

=0.925，95%

：0.859~0.996，

0.05）、LVEF（

=0.930，95%

：0.902~0.960，

0.001）与CHD合并CHF呈负相关；LDL-C（

=1.734，95%

：1.146~2.625，

0.05）、AST（

=1.030，95%

：1.008~1.053，

0.05）、PASP（

=1.172，95%

：1.068~1.286，

=0.001）与CHD合并CHF呈正相关。

结论

SDANN、QT平均QTC间期、白蛋白、LDL-C、AST、PASP和LVEF是CHD合并CHF的相关因素。这些相关因素可辅助临床医生早期识别CHD合并CHF的高风险患者，对及时治疗以延缓病情进展具有重要意义。

Abstract

Objective To explore the correlation of clinical data and 24-hour Holter electrocardiogram in patients with coronary heart disease(CHD) complicated with chronic heart failure(CHF). Methods This retrospective cross-sectional study included 424 patients with CHD who were hospitalized

for diagnosis and treatment at the First Affiliated Hospital of Xinjiang Medical University or four collaborating center hospitals from January 2023 to December 2024. The clinical data during the patients' hospitalization

including age

gender

white blood cells

red blood cells

platelets

estimated glomerular filtration rate (eGFR)

triglycerides (TG)

total cholesterol (TC)

low-density lipoprotein (LDL-C)

glycated hemoglobin

Left ventricular end-diastolic diameter (LVESD)

pulmonary artery systolic pressure (PASP) and left ventricular ejection fraction (LVEF)were all collected.The monitoring indicators of 24-hour Holter electrocardiogram such as the slowest heart rate

the fastest heart rate

the standard deviation of NN intervals (SDNN)

the triangular index

the average QTC interval of QT

and the heart rate deceleration rate (DC) were also collected. The research subjects were divided into the heart failure group (

=227) and the non-heart failure group (

=197) based on whether the CHD patients complicated with CHF. The clinical characteristics of the two groups were compared and the multivariate Logistic regression analysis was used to explore the relevant factors in patients with CHD complicated with CHF. Results Among the indicators monitored by Holter electrocardiogram

the results of multivariate Logistic regression analysis showed that the SDANN index (

=0.943

95%

: 0.906~0.981

0.05) was negatively correlated with CHD combined with CHF; the average QTC interval of QT (

=1.008

95%

: 1.001~1.014

0.05) was positively correlated with CHD combined with CHF. In the clinical data

the results of multivariate Logistic regression analysis showed that the albumin (

=0.925

95%

: 0.859~0.996

0.05)

LVEF (

=0.930

95%

:0.902~0.960

0.001) were n

egatively correlated with CHD combined with CHF; LDL-C (

=1.734

95%

: 1.146~2.625

0.05)

AST(

=1.030

95%

: 1.008~1.053

0.05)

PASP (

=1.172

95%

: 1.068~1.286

0.001) were positively correlated with CHD combined with CHF. Conclusions The SDANN index

average QTc interval of QT

albumin

LDL-C

AST

PASP and LVEF are the relevant factors for CHD combined with CHF. These relevant factors can assist clinicians in identifying high-risk patients with CHD combined with CHF at an early stage

which is of great significance for timely treatment to delay the progression of the disease.

关键词

Keywords

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