心房颤动(atrial fibrillation
房颤)是临床上常见的心律失常
总发病率约为1%。房颤导致脑卒中和心力衰竭的发生风险增加
增加患者的致残率和死亡率。计算机模型、动物模型以及小规模的人体研究发现
心房的复极和折返在房颤的发生机制中起重要作用。Moe的多发子波折返学说认为
心房不应期越短
越容易形成房颤。心房和心室的不应期取决于几种相同的钠离子和钾离子电流
提示了两者之间
Mala C. Mandyam,Elsayed Z. Soliman,Alvaro Alonso,Thomas A. Dewland,Susan R. Heckbert,Eric Vittinghoff,Steven R. Cummings,Patrick T. Ellinor,Bernard R. Chaitman,Karen Stocke,William B. Applegate,Dan E Arking,Javed Butler,Laura R. Loehr,Jared W. Magnani,Rachel A. Murphy,Suzanne Satterfield,Anne B. Newman,Gregory M. Marcus.The QT Interval and Risk of Incident Atrial Fibrillation[J].Heart Rhythm,2013.
Jonas Bille Nielsen,Claus Graff,Adrian Pietersen,Bent Lind,Johannes Jan Struijk,Morten Salling Olesen,Stig Hauns?,Thomas Alexander Gerds,Jesper Hastrup Svendsen,Lars K?ber,Anders Gaarsdal Holst.J-Shaped Association Between QTc Interval Duration and the Risk of Atrial Fibrillation[J].Journal of the American College of Cardiology,2013(25).
High Prevalence of Long QT Syndrome–Associated SCN5A Variants in Patients With Early-Onset Lone Atrial Fibrillation[J].Circulation: Cardiovascular Genetics,2012(4).
Elsayed Z. Soliman,George Howard,Mary Cushman,Brett Kissela,Dawn Kleindorfer,Anh Le,Suzanne Judd,Leslie A. McClure,Virginia J. Howard.Prolongation of QTc and Risk of Stroke[J].Journal of the American College of Cardiology,2012(16).
Niels Voigt,Na Li,Qiongling Wang,Wei Wang,Andrew W. Trafford,Issam Abu-Taha,Qiang Sun,Thomas Wieland,Ursula Ravens,Stanley Nattel,Xander H.T. Wehrens,Dobromir Dobrev.Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation[J].Circulation,2012(17).
I.D. Greener,O. Monfredi,S. Inada,N.J. Chandler,J.O. Tellez,A. Atkinson,M.-A. Taube,R. Billeter,R.H. Anderson,I.R. Efimov,P. Molenaar,D.C. Sigg,V. Sharma,M.R. Boyett,H. Dobrzynski.Molecular architecture of the human specialised atrioventricular conduction axis[J].Journal of Molecular and Cellular Cardiology,2011(4).
Carla Giustetto,Rainer Schimpf,Andrea Mazzanti,Chiara Scrocco,Philippe Maury,Olli Anttonen,Vincent Probst,Jean-Jacques Blanc,Pascal Sbragia,Paola Dalmasso,Martin Borggrefe,Fiorenzo Gaita.Long-Term Follow-Up of Patients With Short QT Syndrome[J].Journal of the American College of Cardiology,2011(6).
William B. Kannel,Emelia J. Benjamin.Current Perceptions of the Epidemiology of Atrial Fibrillation[J].Cardiology Clinics,2009(1).
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