心肌细胞钙信号是电-收缩偶联的关键因素
受多种蛋白激酶的调节。近年来
发现钙动力学紊乱导致异位起搏、传导阻滞、折返等诸多心律失常
其中包括恶性心律失常事件的发生
虽然发病率低
但猝死率高。本文简述钙调控异常与心律失常的关系
为心律失常的机制探索和治疗提供借鉴。一.心肌细胞钙转运过程与钙调控途径(一)心肌细胞钙转运过程Ca2+参与心肌细胞电活动、机械收缩、能量代谢等多种生理过程。正常情况下
胞内钙离子受细胞膜、肌浆网上多种钙转运蛋白的调控
进而参与心脏
Andrew P. Landstrom,Dobromir Dobrev,Xander H.T. Wehrens.Calcium Signaling and Cardiac Arrhythmias[J].Circulation Research,2017(12).
Zhichao Xiao,Wenting Guo,Bo Sun,Donald J. Hunt,Jinhong Wei,Yingjie Liu,Yundi Wang,Ruiwu Wang,Peter P. Jones,Thomas G. Back,S. R. Wayne Chen.Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias[J].Journal of Biological Chemistry,2016.
Xiaowei Zhong,Bo Sun,Alexander Vallmitjana,Tao Mi,Wenting Guo,Mingke Ni,Ruiwu Wang,Ang Guo,Henry J. Duff,Anne M. Gillis,Long-Sheng Song,Leif Hove-Madsen,Raul Benitez,S.R. Wayne Chen.Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts[J].Biochemical Journal,2016.
Michael B. Liu,Enno de Lange,Alan Garfinkel,James N. Weiss,Zhilin Qu.Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue[J].Heart Rhythm,2015.
Dobromir Dobrev,Xander H.T. Wehrens.Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias: Controversies Around Ryanodine Receptor Phosphorylation in Cardiac Disease[J].Circulation Research,2014(8).
Na Li,David Y. Chiang,Sufen Wang,Qiongling Wang,Liang Sun,Niels Voigt,Jonathan L. Respress,Sameer Ather,Darlene G. Skapura,Valerie K. Jordan,Frank T. Horrigan,Wilhelm Schmitz,Frank U. Müller,Miguel Valderrabano,Stanley Nattel,Dobromir Dobrev,Xander H.T. Wehrens.Ryanodine Receptor–Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model[J].Circulation,2014(12).
Maura Greiser,Ulrich Schotten.Dynamic remodeling of intracellular Ca 2<ce:hsp sp="0.10"/>+ signaling during atrial fibrillation[J].Journal of Molecular and Cellular Cardiology,2013.
Ruey J. Sung,Lo,Tien,Hsiao,Yi-Hsin Wang,Jyh-Ming Juang.Gene mutations in cardiac arrhythmias: a review of recent evidence in ion channelopathies[J].The Application of Clinical Genetics,2013(defa).
Donald M. Bers.Calcium Cycling and Signaling in Cardiac Myocytes[J].Annual Review of Physiology,2008.
Loss-of-Function Mutations in the Cardiac Calcium Channel Underlie a New Clinical Entity Characterized by ST-Segment Elevation, Short QT Intervals, and Sudden Cardiac Death[J].Circulation,2007(4).
0
浏览量
252
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621