Objective To investigate the effect of Nexium on elderly patients with ACUTE ST-segment elevation myocardial infarction（STEMI） undergoing Percutaneous coronary intervention（PCI） for cardiac function and myocardial microcirculation perfusion. Methods According to the simple randomization method will March2017 to February 2019

our hospital during the period of 125 routine PCI surgery in elderly patients with STEMI group

control group

62 cases of preoperative for Ticagrelor treatment

postoperative isosorbide mononitrate treatment

observation group based on the control

can be in Bristol

comparing two groups of cardiac function and myocardial microcirculation perfusion and postoperative complications. Results The observation group 6 h

24 h after PCI troponin I（Cardiac Troponin I

cTnI）

Creatine Kinase Isoenzyme（Creatine Kinase Isoenzyme MB

CKMB） and Amino Terminal Brain Natriuretic Peptide Precursor（N-terminal proBNP

NT-proBNP） level was lower than those of control group

1 week after PCI LVEF was higher than control group（p<0.05）; The sum of blood flow velocity

myocardial blood flow and capillary cross-sectional area after PCI in the observation group was higher than that in the control group（p<0.05）. The incidence of postoperative complications in the observation group（4.76%） was lower than that in the control group（16.29%）（p<0.05）. Conclusions Nicoterl can reduce the cardiac function injury of elderly patients after STEMIPCI

improve myocardial microcirculation perfusion

and reduce the risk of postoperative complications.