Ito电流在冠心病多形性室速发生中的作用及奎尼丁的预防机制

时向民; 李健; 李世兴; 张闯

您当前的位置：

首页 >

文章列表页 >

Ito电流在冠心病多形性室速发生中的作用及奎尼丁的预防机制

综述 | 更新时间：2025-10-15

- Ito电流在冠心病多形性室速发生中的作用及奎尼丁的预防机制
- The role of transient outward potassium current in the arrhythmogenesis of polymorphic ventricular tachycardia in patients with coronary artery disease and the prophylactic mechanism of quinidine
- 临床心电学杂志 2022年第1期页码：65-68
- 作者机构：
  
  中国人民解放军总医院心血管病医学部
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R541.7
- 纸质出版：2022
- 稿件说明：
移动端阅览
时向民, 李健, 李世兴, 等. Ito电流在冠心病多形性室速发生中的作用及奎尼丁的预防机制[J]. 临床心电学杂志, 2022,(1):65-68.

Shixiangmin, Li jian, Li shixing, et al. The role of transient outward potassium current in the arrhythmogenesis of polymorphic ventricular tachycardia in patients with coronary artery disease and the prophylactic mechanism of quinidine[J]. 2022, (1): 65-68.
时向民, 李健, 李世兴, 等. Ito电流在冠心病多形性室速发生中的作用及奎尼丁的预防机制[J]. 临床心电学杂志, 2022,(1):65-68. DOI：

Shixiangmin, Li jian, Li shixing, et al. The role of transient outward potassium current in the arrhythmogenesis of polymorphic ventricular tachycardia in patients with coronary artery disease and the prophylactic mechanism of quinidine[J]. 2022, (1): 65-68. DOI：

摘要

短联律间期室早引发的多形性室性心动过速（PVT）是冠心病（CAD）患者常见的危及生命的心律失常之一，血运重建和传统的抗心律失常药物无法有效预防这种恶性心律失常。最近的研究表明，2相折返可能是心肌缺血相关PVT的潜在机制，这与Brugada综合征和特发性心室颤动的发生机制相类似。瞬时外向钾电流（Ito）在2相折返的形成中起重要作用，奎尼丁已被证实可抑制Ito并预防CAD患者PVT的发生。

Abstract

Polymorphic ventricular tachycardia（PVT） triggered by short-coupled premature ventricular complex is a common life-threatening arrhythmia in coronary artery disease（CAD）

revascularization and traditional anti-arrhythmic drugs could not effectively prevent this malignant arrhythmia. Recent study suggested that phase 2reentry could be the underlying mechanism of myocardial ischemia-related PVT

which was similar to that of Brugada syndrome and idiopathic ventricular fibrillation. Transient outward potassium current（Ito） plays an important role in the development of phase 2 reentry

and quinidine has been proved to inhibit Ito and prevent the occurrence of PVT in patients with CAD.

关键词

Keywords

references

Polymorphic ventricular tachycardia, ischaemic ventricular fibrillation, and torsade de pointes: importance of the QT and the coupling interval in the differential diagnosis[J]. Rosso Raphael;Hochstadt Aviram;Viskin Dana;Chorin Ehud;Schwartz Arie Lorin;Tovia-Brodie Oholi;Laish-Farkash Avishag;Havakuk Ofer;Gepstein Lior;Banai Shmuel;Viskin Sami.European Heart Journal,2021(38)

Polymorphic Ventricular Tachycardia: Terminology, Mechanism, Diagnosis, and Emergency Therapy[J]. Viskin Sami;Chorin Ehud;Viskin Dana;Hochstadt Aviram;Schwartz Arie Lorin;Rosso Raphael.Circulation,2021(10)

The case for quinidine: Management of electrical storm in refractory ventricular fibrillation[J]. Rebecca Pinnelas;Julie Friedman;Claudia Gidea;Eugene Yuriditsky;Larry Chinitz;Marina Cerrone;Lior Jankelson.HeartRhythm Case Reports,2020(7)

Quinidine-responsive out-of-hospital polymorphic ventricular tachycardia in patients with coronary heart disease.[J]. Viskin Sami;Hochstadt Aviram;Chorin Ehud;Viskin Dana;Havakuk Ofer;Khoury Shafik;Lee John K;Belhassen Bernard;Rosso Raphael.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of,2020(2)

Ventricular Fibrillation After Ablation of a Benign Arrhythmia. Angry Purkinje Syndrome?[J]. Sami Viskin;Arie Lorin Schwartz;Yuval Levi;Raphael Rosso.HeartRhythm Case Reports,2020(prep)

Quinidine-Responsive Polymorphic Ventricular Tachycardia in Patients With Coronary Heart Disease.[J]. Viskin Sami;Chorin Ehud;Viskin Dana;Hochstadt Aviram;Halkin Amir;Tovia-Brodie Oholi;Lee John K;Asher Elad;Laish-Farkash Avishag;Amit Guy;Havakuk Ofer;Belhassen Bernard;Rosso Raphael.Circulation,2019(20)

Modernized Classification of Cardiac Antiarrhythmic Drugs.[J]. Lei Ming;Wu Lin;Terrar Derek A;Huang Christopher L-H.Circulation,2018(17)

Present Status of Brugada Syndrome[J]. Josep Brugada;Oscar Campuzano;Elena Arbelo;Georgia Sarquella-Brugada;Ramon Brugada.Journal of the American College of Cardiology,2018(9)

J wave syndromes as a cause of malignant cardiac arrhythmias.[J]. Di Diego José M;Antzelevitch Charles.Pacing and clinical electrophysiology : PACE,2018(7)

Pharmacological Therapy in Brugada Syndrome.[J]. Brodie Oholi Tovia;Michowitz Yoav;Belhassen Bernard.Arrhythmia & electrophysiology review,2018(2)

Management of Brugada Syndrome 2016: Should All High Risk Patients Receive an ICD? Alternatives to Implantable Cardiac Defibrillator Therapy for Brugada Syndrome.[J]. Belhassen Bernard.Circulation. Arrhythmia and electrophysiology,2016(11)

Ventricular arrhythmias and the His-Purkinje system.[J]. Haissaguerre Michel;Vigmond Edward;Stuyvers Bruno;Hocini Meleze;Bernus Olivier.Nature reviews. Cardiology,2016(3)

Effect of Wenxin Keli and quinidine to suppress arrhythmogenesis in an experimental model of Brugada syndrome[J]. Yoshino Minoura;Brian K. Panama;Vladislav V. Nesterenko;Matthew Betzenhauser;Hector Barajas-Martínez;Dan Hu;José M. Di Diego;Charles Antzelevitch.Heart Rhythm,2013(7)

A comparison of transient outward currents in canine cardiac Purkinje cells and ventricular myocytes.[J]. Han W;Wang Z;Nattel S.American journal of physiology. Heart and circulatory physiology,2000(2)

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

暂无数据