Objective To explore the variation of dipper heart rate

non-dipper heart rate and heart rate in hypertensive patients with poor prognosis and the relationship with heart rate variation（HRV） and the effect of increased heart rate on prognosis. Methods One hundred and sixty four patients with hypertension were randomly selected and 134 patients were followed up for 0.5-3 years. The patients were divided into three groups: dipper heart rate group

non-dipper heart rate group and adverse event group. All patients were monitored by 24 h Holter. Observe resting heart rate（RHR）

average heart rate（AHR）

night heart rate（NHR）

day heart rate（DHR）

LF

HF（the quantitative index of heart rate variability） and analyzed by SPSS 15.0 Statistical software. Results Comparing Non-dipper heart rate group with dipper heart rate group. The value of LF decreased at day

and the value of LF

HF were significantly lower at night（p<0.05）; RHR

AHR

NHR were significantly higher（p<0.001

p<0.05）. Comparing night with day in group of dipper heart rate

the mean of LF

HF were significantly higher（p<0.05）

but the value of LF/HF at day was higher than that at night. Comparing the event group with the non-dipper group: LF

HF at day and night were significantly lower（p<0.001）

and RHR

AHR

NHR and DHR were significantly higher（p<0.001）.Conclusions With the progressive aggravation of hypertension patients

heart rate gradually accelerated. The 24 h average heart rate was more than 82 beats/min

and the HRV decreased progressively.This chronic heart rate increase was the result of excessive activation of the sympathetic nerve and excessive inhibition of the vagus nerve

and gradual exhaustion of autonomic nerve function.