Objective To observe the clinical effect and changes of neuroendocrine factors and hemodynamics of patients with rheumatic heart disease（RHD） with moderate mitral stenosis（MS） after the application of intensive antihypertensive regimen. Methods A total of 87 patients with moderate mitral stenosis of rheumatic heart disease in our department from February 2019 to February 2021 were selected as the research objects

and they were divided into control group（n =43） and observation group（n =44） by computer random sampling method. The control group（n=43） received diuretics

digitoxin and other conventional drugs. Observation group 44 cases of nifedipine combined with metoprolol enhanced antihypertensive regimen

the treatment effect

cardiac function indicators

hemodynamic indicators

neuroendocrine factor levels and adverse reactions of the two groups were compared. Results After treatment

LVEF

LVET and E/A were increased in 2 groups

while HR

LVESV

LVEDV

m MPG

mPAP

mLAP

BNP and Hs-CRP levels were decreased in the observation group. The changes of various indicators were greater in the observation group. The total effective rate of observation group and control group was 90.91% and 74.42%. The observation group had good curative effect（p<0.05）. The total incidence of adverse reactions in the observation group and the control group was 6.82% and 9.30%

and there was no significant difference in the incidence of adverse reactions between the two groups（p>0.05）. Conclusions In patients with rheumatic heart disease with moderate mitral stenosis

the clinical effect of intensive antihypertensive program is good

and the hemodynamics

myocardial injury index and cardiac function are improved.