Objective To analyze the effects of low-dose dabigatran on the incidence of end-point events

vascular endothelial and coagulation function in elderly patients with NVAF complicated with mild to moderate chronic kidney injury. Methods Total 121 elderly patients enrolled into our department between January 2018 to October 2020 who had nonvalvular atrial fibrillation with mild-to-moderate chronic renal damage 60 cases were treated with warfarin

the observation group 61 patients were given low doses of dabigatrun. We compared the two groups of patients with vascular endothelial function

blood coagulation function

blood biochemical indices

incidence of embolism or thrombosis

and bleeding events. Results After 6 months of treatment

there were no significant differences in alanine aminotransferase

fasting blood glucose

TC

creatinine and bilirubin levels between the observation group and the control group（p>0.05）. After 6 months of treatment

CEC and ET-1 scores in the observation group were lower than those in the control group（p<0.05）. PT

TT

FIB and APTT levels were higher than those in control group（p <0.05）. There was no significant difference in the incidence of thromboembolism between the observation group and the control group（p>0.05）

and the bleeding events in the observation group were lower than those in the control group（p<0.05）. Conclusions Low dose of dabigatrun in the treatment of NFAF patients with moderate to mild chronic renal injury has a significant effect

high safety

can reduce the risk of bleeding events

improve the coagulation function

is beneficial to reduce the injury of vascular endothelial.