Objective To investigate the effect of esmolol assisted amiodarone on ECG and cardiac function in patients with coronary heart disease complicated with rapid arrhythmia. Methods Nity-four patients with coronary heart disease and tachyarrhythmia were randomly divided into experimental group and control group

47 cases in each group. The control group was treated with amiodarone

and the experimental group was treated with amiodarone and esmolol. The cardiac function indexes of the two groups were compared before and after treatment（LVEF）

cardiac output（CO）

left ventricular end systolic diameter（LVESD）

left ventricular end diastolic diameter（LVEDd）

dynamic electrocardiogram index [PR interval

QTc interval

ventricular pre systolic（PVC）

short array ventricular tachycardia] The changes of myocardial marker levels（CK MB）

NT pro BNP in the precursor of nerve terminal were observed; The adverse drug reactions（liver dysfunction

hypotension

sinus heart rate bradycardia） were recorded.Results LVEF and CO in both groups were significantly higher than those before treatment

and the experimental group was significantly higher than that in the control group（p<0.05）

The LVESD and LVEDd in the two groups were significantly lower than that before treatment（p<0.05）

and the experimental group was significantly lower than that of the control group（p<0.05）

The PR interval and QTc interval of ECG in the two groups were significantly longer than that before treatment（p<0.05）

and the experimental group was significantly longer than that of the control group（p<0.05）. The results showed that the PVC and short array ventricular tachycardia in the two groups were significantly lower than that before treatment（p<0.05）

and the experimental group was significantly lower than that of the control group（p<0.05）. After 48 hours of treatment

the serum CK MB and NT pro BNP levels of the two groups were significantly lower than before treatment（p<0.05）

but the difference was not statistically significant（p>0.05）;The total incidence of adverse drug reactions in the experimental group was significantly lower than that of the control group（p<0.05）. Conclusions Esmolol assisted amiodarone has good effect in the patients with coronary heart disease and tachyarrhythmia

which can improve the ECG index and cardiac function.