目的 探讨血清ICAM-1、sd-LDL、脂蛋白a检测对冠心病患者的诊断价值。方法 本研究以本院2022年1月至2023年6月住院的60例冠心病患者为研究组,并以50例健康体检者为对照组。比较两组ICAM-1、sd-LDL、脂蛋白a水平,ICAM-1、sd-LDL、脂蛋白a单独和组合检测阳性率,并用ROC曲线进行比较。结果 在性别、年龄、吸烟和饮酒情况、总胆固醇水平、高血压、糖尿病和高血脂病史等方面,两组之间没有统计学差异,(P>0.05);与对照组比较,研究组的甘油三酯和低密度脂蛋白胆固醇水平较高,高密度脂蛋白胆固醇较(P<0.05)。研究组ICAM-1、sd-LDL、脂蛋白a水平与对照组相比,显著较高(P<0.05)。与轻度患者相比,中度、重度患者ICAM-1、sd-LDL、脂蛋白a水平较高;与中度症状患者相比,轻度患者ICAM-1、sd-LDL、脂蛋白a水平较低,重度患者ICAM-1、sd-LDL、脂蛋白a水平较高(P<0.05)。ICAM-1、sd-LDL、脂蛋白a单项检测检出阳性率明显低于三项联合检测阳性率(P<0.05)。三者联合检测的灵敏度、特异度和准确度分别是(95.08、95.91、95.45)、阳性/阴性预测值分别是(96.66、94.00)均高于ICAM-1、sd-LDL、脂蛋白a单项检测的灵敏度、特异度和准确度及阳性/阴性预测值,对冠心病患者检出率较高。结论 血清ICAM-1、sd-LDL和脂蛋白a均与冠心病密切相关,且三项指标联合测定能显著提高其检出率,是一种具有较好临床价值的辅助诊断指标,具有较好的临床应用价值。
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