467000 河南 平顶山,平顶山市第一人民医院心脏大血管外科
游瑞,男,主治医师,研究方向:心脏外科手术。
收稿:2025-12-18,
修回:2026-01-26,
录用:2026-01-29,
纸质出版:2026-02-28
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游瑞, 赵东敏, 李文博. 老年冠心病患者不停跳冠脉搭桥术后发生房颤的影响因素分析[J]. 临床心电学杂志, 2026, 35(1): 28-34.
YOU Rui,ZHAO Dongmin,LI Wenbo..Analysis of influencing factors of atrial fibrillation after off-pump coronary artery bypass grafting in elderly patients with coronary heart disease[J].J Clin Electrocardiol,2026,35(01):28-34.
游瑞, 赵东敏, 李文博. 老年冠心病患者不停跳冠脉搭桥术后发生房颤的影响因素分析[J]. 临床心电学杂志, 2026, 35(1): 28-34. DOI:
YOU Rui,ZHAO Dongmin,LI Wenbo..Analysis of influencing factors of atrial fibrillation after off-pump coronary artery bypass grafting in elderly patients with coronary heart disease[J].J Clin Electrocardiol,2026,35(01):28-34. DOI:
目的
2
探讨老年冠心病患者不停跳冠脉搭桥术(OPCABG)术后发生房颤的影响因素,并建立预测模型,以指导临床制定干预方案。
方法
2
前瞻性选取2023年1月~2025年1月于平顶山市第一人民医院心脏大血管外科就诊的178例老年冠心病患者为研究对象,均予以OPCABG治疗,依据OPCABG术后5 d内是否发生房颤将其分为发生组55例、未发生组123例。比较两组一般资料,并分析术后房颤发生的影响因素。构建预测模型,并通过ROC曲线、Hosmer-Lemeshow拟合优度检验、校准曲线、决策曲线(DCA)评估预测模型的预测效能、准确性及临床效用性。
结果
2
多因素Logistic回归分析显示术前左心房内径、置入支架数量、NYHA心功能分级、高血压史、冠状动脉中重度钙化及术前血清生长分化因子15(GDF-15)、半乳糖凝集素3(Gal-3)、内脂素(Visfatin)水平为术后房颤发生的独立危险因素(
P
<
0.05);Logit(
p
)=-0.745+0.868×术前左心房内径+1.460×置入支架数量+1.575×NYHA心功能分级+1.371×高血压史+1.424×冠状动脉中重度钙化+0.771×GDF-15+0.765×Gal-3+0.901×Visfatin;预测模型预测术后房颤发生风险的AUC值为0.890,敏感度、特异度分别为85.45%、82.93%,该模型预测结果与实际观测结果一致性较好,且具有良好的临床效用性。
结论
2
术前左心房内径、置入支架数量、NYHA心功能分级、高血压史、冠状动脉中重度钙化及术前血清GDF-15、Gal-3、Visfatin水平为老年冠心病患者术后房颤发生的独立危险因素,基于上述模型建立预测模型,该模型对术后房颤发生具有良好的预测价值,临床应针对上述因素进行积极干预,以减少术后房颤发生。
Objective To investigate the influencing factors of atrial fibrillation after off-pump coronary artery bypass grafting (OPCABG) in elderly patients with coronary heart disease (CHD)
and to establish a predictive model to guide clinical intervention. Methods A total of 178 elderly patients with coronary heart disease who were treated in our hospital from January 2023 to January 2025 were prospectively selected as the research objects. All patients were treated with OPCABG. According to whether atrial fibrillation occurred within 5 days after OPCABG
they were divided into 55 cases in the occurrence group and 123 cases in the non-occurrence group. The general data of the two groups were compared
and the influencing factors of postoperative atrial fibrillation were analyzed. The prediction model was constructed
and the prediction efficiency
accuracy and clinical utility of the prediction model were evaluated by ROC curve
Hosmer-Lemeshow goodness of fit test
calibration curve and decision curve (DCA). Results Multivariate Logistic regre
ssion analysis showed that preoperative left atrial diameter
number of implanted stents
NYHA cardiac function classification
history of hypertension
moderate to severe coronary artery calcification and preoperative serum growth differentiation factor 15 (GDF-15)
galactose lectin 3 (Gal-3)
Visfatin levels were independent risk factors for postoperative atrial fibrillation (
P
<
0.05). Logit (
p
) = -0.745 + 0.868 × preoperative left atrial diameter + 1.460 × number of implanted stents + 1.575 × NYHA cardiac function classification + 1.371 × history of hypertension + 1.424 × moderate to severe coronary artery calcification + 0.771 × GDF-15 + 0.765 × Gal-3 + 0.901 × Visfatin; the AUC value of the prediction model for predicting the risk of postoperative atrial fibrillation was 0.890
the sensitivity and specificity were 85.45% and 82.93%
respectively. The prediction results of the model were in good agreement with the actual observation results
and had good clinical utility. Conclusions Preoperative left atrial diameter
number of implanted stents
NYHA cardiac function classification
history of hypertension
moderate to severe coronary artery calcification
and preoperative serum GDF-15
Gal-3
and Visfatin levels are independent risk factors for postoperative atrial fibrillation in elderly patients with coronary heart disease. Based on the above model
a prediction model was established. The model has a good predictive value for postoperative atrial fibrillation. Clinically
active intervention should be performed on the above factors to reduce postoperative atrial fibrillation.
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